What new treatments for ED are being developed in the USA?

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What new treatments for ED are being developed in the USA?

New developments in erectile dysfunction (ED) treatment in the United States have introduced a range of innovative alternatives, beyond the traditional medications. Below is an overview of some of the most innovative new treatments:

1. Eroxon® (MED3000): Over-the-Counter Topical Gel
Eroxon is the first over-the-counter topical gel for erectile dysfunction approved by the FDA. It is used directly on the penis and has an effect in 10 minutes by stimulating nerve endings with a cooling sensation that eventually warms. This instant, non-surgical treatment is a discreet option for men seeking relief immediately.
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2. Priapus Toxin (Botulinum Toxin Injections)
Priapus toxin is the intracavernosal injection of botulinum toxin to relax smooth muscle and increase blood flow. It has been promising to enhance erectile function, with duration of action ranging from several months. It’s particularly reserved for men who are not responsive to oral medications.
genesislifestylemedicine.com

3. Low-Intensity Shockwave Therapy (LISWT)
LISWT employs acoustic waves to stimulate blood circulation and facilitate tissue repair of the penis. The non-surgical procedure has gained popularity due to its possible restoration of spontaneous erectile function in men, particularly those with vascular ED.
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4. Platelet-Rich Plasma (PRP) Therapy
PRP therapy, or the “P-Shot,” is a treatment in which concentrated platelets from the patient’s own blood are injected into the penis. The growth factors in PRP are believed to promote tissue growth and improve erectile function. While some studies have shown positive outcomes, more research is needed to completely establish its efficacy.
Katelaris Urology Syndey & North Shore
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5. Bremelanotide and PDE5 Inhibitor Combination
Phase 2 clinical trials are testing the combination of bremelanotide, a melanocortin receptor agonist, and conventional PDE5 inhibitors like sildenafil. This is to enhance erectile response using different mechanisms of sexual stimulation.

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6. Vertica: Home-Use Radiofrequency Device
Vertica is a device used at home to stimulate penile tissue using radiofrequency energy, which provokes blood flow and potentially improves erectile function. Clinical trials were said to be indicating significant improvements in erectile function in the early trials, but more studies are needed to confirm its long-term impact.
The Sun

7. Smartphone-Controlled Penile Prostheses
In the future, researchers are creating electronically controlled penile prostheses that can be controlled via smartphones. The idea is to have a more personalized and convenient solution for men with advanced ED so that men can enjoy more control over the firmness and duration of erection.
The Sun

These advances reflect an emphasis on individualized and less invasive therapies for ED. Those men with erectile dysfunction should speak with a physician to explore these options and the most suitable option based on each person’s general health needs and wants.

Recent medications for the treatment of erectile dysfunction (ED) work best for most men, but how effectively they will do so is subject to individual circumstances like the cause of ED, age, lifestyle, and overall health. What follows is the explanation of most commonly prescribed medication and its effectiveness:

1. PDE5 Inhibitors
These are the first-line of treatment for ED and are effective in about 60-80% of men.

They are effective for most men with ED, especially if the etiology is primarily physiological (i.e., vascular or hormonal in nature). They stimulate increased penile blood flow with stimulation.

Common PDE5 Inhibitors:
Sildenafil (Viagra)

Tadalafil (Cialis)

Vardenafil (Levitra)

Avanafil (Stendra)

Effectiveness
Sildenafil (Viagra): Works in 30-60 minutes, lasts 4-5 hours. Ideal for men with ED due to vascular disease or diabetes.

Tadalafil (Cialis): Longer duration of action, 36 hours, thus favored for spontaneous sex.

Vardenafil and Avanafil: Generally have quicker onset (15-30 minutes) and fewer side effects than sildenafil.

2. Hormone Therapy
In men with low testosterone (hypogonadism), hormone replacement therapy (HRT) can help sexual function, particularly if low testosterone is the underlying cause of ED.

Hormone Therapy Types:
Testosterone Replacement Therapy (TRT): Injections, patches, gels, or pellets.

Effectiveness: Low-testosterone men on TRT will often report improved libido and erectile function, although its utility for ED will not be so striking if there is another etiology (e.g., vascular) present.

3. Prostaglandin E1 Injections and Suppositories
Alprostadil (Caverject) is a self-injection that increases blood flow to the penis and typically is used when PDE5 medications fail.

Effectiveness: Alprostadil is highly effective, with approximately 70-80% success in diabetic or nerve damage-caused erectile dysfunction in men.

4. Vacuum Erection Devices (VED)
Effectiveness: Vacuum pumps can cause an erection in approximately 90% of men who use them, though maybe not as spontaneous or comfortable as drugs.

These are especially useful in men who cannot take oral drugs due to contraindications (e.g., men with cardiovascular disease or on nitrates).

5. Penile Implants
As a permanent solution for severe ED or failure of other therapy, penile implants involve surgical insertion of a device that facilitates controlled erections.

Effectiveness: Penile implants have excellent success (greater than 90%) and are a last-option treatment.

6. Low-Intensity Extracorporeal Shockwave Therapy (Li-ESWT)
This is a nonsurgical procedure that uses sound waves to increase blood flow to the penis.

Effectiveness: Emerging research suggests that shockwave therapy works for men with vascular ED, but it is still in research and not yet FDA-approved as a first-line treatment.

7. Lifestyle Changes & Supplements
Diet, exercise, and stress reduction have a substantial impact on ED. The use of exercise and removal of risk factors (like smoking and obesity) can improve erectile function.

Supplements: While some supplements (like L-arginine, ginseng, and yohimbine) show promise, their effectiveness is not as well documented as with prescription medications.

##### Limitations and Side Effects
PDE5 Inhibitors are most likely to have side effects of headache, flushing, nasal congestion, and vision changes. They are not recommended for men on nitrates or with severe cardiovascular disease.

Hormone Therapy: May cause weight gain, mood swings, and prostate issues.

Injection Therapy: May cause pain, bruising, and scarring in the injection area.

Vacuum Pumps: Are cumbersome and require time to get used to.

Conclusion
Ed’s medications today benefit the majority of men, especially if the problem is due to physiological reasons like vascular integrity or endocrine irregularities. Nevertheless, success still hinges on why ED occurred as well as with other illnesses. In psychological ED or in difficult cases, combined treatment that combines medication, guidance, and adjustment of lifestyle patterns may be indicated.

Would you prefer information regarding a particular treatment for ED or ongoing research in this area?